Informed consent is a key condition for prenatal screening programmes to reach their aim of promoting reproductive autonomy. Reaching this aim is currently being challenged with the introduction of non-invasive prenatal testing (NIPT) in first-trimester prenatal screening programmes: amongst others its procedural ease—it only requires a blood draw and reaches high levels of reliability—might hinder women’s understanding that they should make a personal, informed decision about screening. We offer arguments for a renewed recognition and use of informed consent compared to (...) informed choice, and for a focus on value-consistent choices and personalized informational preferences. We argue for a three-step counselling model in which three decision moments are distinguished and differently addressed: (1) professionals explore women’s values concerning whether and why they wish to know whether their baby has a genetic disorder; (2) women receive layered medical-technical information and are asked to make a decision about screening; (3) during post-test counselling, women are supported in decision-making about the continuation or termination of their pregnancy. This model might also be applicable in other fields of genetic (pre-test) counselling, where techniques for expanding genome analysis and burdensome test-outcomes challenge counselling of patients. (shrink)

To what degree has biology influenced and shaped the development of moral systems? One way to determine the extent to which human moral systems might be the product of natural selection is to explore behaviour in other species that is analogous and perhaps homologous to our own. Many non-human primates, for example, have similar methods to humans for resolving, managing, and preventing conflicts of interests within their groups. Such methods, which include reciprocity and food sharing, reconciliation, consolation, conflict intervention, and (...) mediation, are the very building blocks of moral systems in that they are based on and facilitate cohesion among individuals and reflect a concerted effort by community members to find shared solutions to social conflict. Furthermore, these methods of resource distribution and conflict resolution often require or make use of capacities for empathy, sympathy, and sometimes even community concern. Non-human primates in societies in which such mechanisms are present may not be exactly moral beings, but they do show signs of a sense of social regularity that—just like the norms and rules underlying human moral conduct—promotes a mutually satisfactory modus vivendi. (shrink)

Este artículo afronta el concepto de “laicidad”. El primer paso es clarificar los distintos términos y sobre todo los conceptos que se usan en este argumento. Después se hace un recorrido por la historia del cristianismo sobre la laicidad, comenzando por el comportamiento del mismo Jesús. En la Iglesia se fue pasando de esta situación a la más rígida sacralización del cristianismo hasta convertirlo en una verdadera “religión”, aunque por encima de todas las demás. En este camino, después de siglos, (...) el Concilio Vaticano II ha superado la situación anterior de sociedad sacralizada, a la distinción y separación neta entre el plano social y el plano eclesial. Este cambio lleva a consecuencias claras y concretas tanto de puertas adentro de la Iglesia, como en su relación con la sociedad laica en que vive la propia institución eclesial como cada cristiano personalmente. (shrink)

Drawing its strength from the UN Charter and UDHR, human rights ethics is a beacon of hope and a promise that requires continuous reaffirmation during these turbulent times. These two documents, with their unwavering faith in ‘fundamental human rights, in the dignity and worth of the human person, in the equal rights of men and women and of nations large and small,’ have shaped our understanding of human rights as global and universal ethics. However, this faith is now being severely (...) tested by four countercurrents: extremism, exclusionism, selectivism, and populism. These countercurrents pose significant and urgent human rights threats that activists, academics, and policymakers must confront by reasserting the basic core values of the UN Charter and UDHR. (shrink)

“Para que isso servirá em minha vida?” Ao longo de minha trajetória como professor do ensino secundário, ouvi esta pergunta algumas vezes. É provável que nós professores de filosofia não sejamos um alvo privilegiado dessa pergunta provocadora. Trata-se mesmo de uma questão legítima, ainda mais para nós: latinoamericanos, brasileiros, nordestinos, piauienses. Trata-se de uma pergunta que evoca um certo desespero, uma certa pressa, um tipo de agonia que é bem nossa; como quando dizemos “estou agoniado”. Queremos tudo “pra já”. Parece (...) que jamais nos daremos o direito de viver e aprender algo pelo simples fato de que o saber é bom e merece ser fruído. (shrink)

Partiendo de la invitación hecha por el Papa Juan Pablo II en su Carta Apostólica "Tertio Millennio Adveniente" a reflexionar sobre la estrecha relación existente entre los misterios de la Encarnación y de la Eucaristía (perspectiva central del Jubileo 2000: TM 55), este trabajo estudia en profundidad las claves bíblicas y teológicas desde las que estos dos misterios que se pueden ver y considerar. Entre las muchas claves desde las que sería posible leer e interpretar estos misterios, este trabajo ha (...) seleccionado seis de ellas, que perfectamente aplicables a ambos misterios, y que constituyen el hilo conductor de la presente reflexión: el trinitario, el pascual, la unidad, la presencia mutuamente vinculante y redentora, la plenitud y las claves marianas. (shrink)

Abordamos en este trabajo la imagen de Dios que nos revela el cántico evangélico del Magnificat (Lucas 1, 46-55) y la imagen de María que en él aparece. Partiendo de su contexto en la obra de Lucas y de un breve análisis exegético del cántico, los autores profundizan en sus claves teológicas en relación con dos núcleos: la imagen de Dios y la figura de María introducida por el evangelista. El trabajo concluye con una propuesta de relectura del Magnficat acorde (...) con nuestro tiempo, centrada en su dimensión profética y liberadora. (shrink)

In De Partibus Animalium I Aristotle sets out his philosophy of biology, discussing cause, necessity, soul, genus, and species, definition by logical division, and general methodology. In De Generatione Animalium I he applies his hylomorphic philosophy to the problem of animal reproduction. The translation is close, and includes passages from De Generatione Animalium II which complete Aristotle's theory of reproduction. The notes interpret Aristotle's arguments and discuss his views on major issues such as natural teleology. The original edition was published (...) in 1972. (shrink)

Cell line immortalisation is a growing component of African genomics research and biobanking. However, little is known about the factors influencing consent to cell line creation and immortalisation in African research settings. We contribute to addressing this gap by exploring three questions in a sample of Xhosa participants recruited for a South African psychiatric genomics study: First, what proportion of participants consented to cell line storage? Second, what were predictors of this consent? Third, what questions were raised by participants during (...) this consent process? 760 Xhose people with schizophrenia and 760 controls were matched to sex, age, level of education and recruitment region. We used descriptive statistics to determine the proportion of participants who consented to cell line creation and immortalization. Logistic regression methods were used to examine the predictors of consent. Reflections from study recruiters were elicited and discussed to identify key questions raised by participants about consent. Approximately 40% of participants consented to cell line storage. The recruiter who sought consent was a strong predictor of participant’s consent. Participants recruited from the South African Eastern Cape, and older participants, were more likely to consent; both these groups were more likely to hold traditional Xhosa values. Neither illness nor education were significant predictors of consent. Key questions raised by participants included two broad themes: clarification of what cell immortalisation means, and issues around individual and community benefit. These findings provide guidance on the proportion of participants likely to consent to cell line immortalisation in genomics research in Africa, and reinforce the important and influential role that study recruiters play during seeking of this consent. Our results reinforce the cultural and contextual factors underpinning consent choices, particularly around sharing and reciprocity. Finally, these results provide support for the growing literature challenging the stigmatizing perception that people with severe mental illness are overly vulnerable as a target group for heath research and specifically genomics studies. (shrink)

With modern technological advances, distance education has become an increasingly important education delivery medium for, for example, the higher education provided by open universities. Among predictive factors of successful learning in distance education, the effects of non-cognitive skills are less explored. Grit, the dispositional tendency to sustain trait-level passion and long-term goals, has raised much research interest and gained importance for predicting academic achievement. The Grit Questionnaire, measuring Perseverance of Effort and Consistency of Interests, has been shown to be a (...) reliable instrument in traditional university student populations. However, the measurement and predictive validity of this questionnaire is still unknown for adult distance education university students who differ from traditional students in various ways. Based on a sample of 2,027 students from a distance education university, this study assessed the psychometric properties of the two-factor structure grit measured by the Grit Questionnaire. The findings suggest that the short form of the Grit Questionnaire is a potentially useful assessment tool for measuring the grit construct for distance learning higher education and that the Consistency of Interests factor is especially relevant to consider the improvement of learning performance for distance education in terms of courses credit and exam attempts. The measurement precision of the Perseverance of Effort factor, however, should be improved in future research to provide higher measurement accuracy and broader item coverage. (shrink)

The second volume of the Adagia of the Amsterdam edition of the Latin texts of Erasmus gives an introduction in German and a critical edition of the Latin text of the second half of the first thousand Adages.

Part Four of the Amsterdam edition of the Latin text of Erasmus’ Annotations to the New Testament presents his notes on St. Paul’s letters to the Corinthians.

The series of policy positions of the US administration in the opening years of the “biotech century” in respect to cloning, embryonic stem cell research, and the patenting of human embryos offers a case study in the development of public policy that, though it has been developed in the context of secular argument, reflects distinctive concerns of Christian theology. Through several events, the Bush administration has confronted a series of policy decisions affecting the ethical-legal framework for biotechnology. Though there has (...) been little explicitly Christian reflection within the bioethics community, Christians together with other thinkers have recognized that these questions could determine the scope and course of developments in biotechnology. (shrink)

From an interdisciplinary perspective the authors of this book, scholars in theology and religious studies, give an account of the problematic and promising aspects of biblically based monotheism, considered as a formative religious idea, belief, and practice in Western history and culture.

In this work we deal with a general class of spatially distributed periodic SIS epidemic models with two time scales. We let susceptible and infected individuals migrate between patches with periodic time dependent migration rates. The existence of two time scales in the system allows to describe certain features of the asymptotic behavior of its solutions with the help of a less dimensional, aggregated, system. We derive global reproduction numbers governing the general spatially distributed nonautonomous system through the aggregated system. (...) We apply this result when the mass action law and the frequency dependent transmission law are considered. Comparing these global reproductive numbers to their non spatially distributed counterparts yields the following: adequate periodic migration rates allow global persistence or eradication of epidemics where locally, in absence of migrations, the contrary is expected. (shrink)